REPORT OF THE NANDS
COUNCIL WORKING
GROUP FOR ME/CFS
RESEARCH
September 4, 2019
(Provides a nice overview of ME/CFS up to 2019…)
“Over the past 35 years, many studies have found abnormalities in the central and autonomic
nervous systems, chronic immune activation or exhaustion, and abnormalities of energy
metabolism, in people with ME/CFS. Clinical ME/CFS research has identified the wide range of
symptoms experienced by people with ME/CFS, and the increased frequency of certain
comorbid conditions, such as fibromyalgia and irritable bowel syndrome. Clinical research also
has identified some potential physical examination findings and standard laboratory test results
that may distinguish people with ME/CFS from healthy controls and is examining whether past
medical history or family history findings may be characteristic of ME/CFS. Many recent
laboratory and clinical research findings were presented in April 2019 at the “Accelerating
Research on ME/CFS” conference held on the NIH campus1
. The conference and general ME/CFS research landscape were summarized in a recent JAMA publication (Komaroff, 2019)2”
